Endocrine Abstracts

Context: Osmotic stimulus or stress results in release of vasopressin. Animal studies have shown that inflammatory parameters such as interleukin-6 (IL-6) and interleukin-8 (IL-8) increase in parallel, mainly in central brain regions. Whether osmotic stimulation leads to an inflammatory response in humans is unknown. We therefore investigated the influence of osmotic stimulation on the inflammatory system in healthy volunteers.Method: In this prospective...

Background: Postprandial hypoglycemia is an increasingly recognized complication after bariatric surgery. Its hallmark is a pronounced glycemic rise after carbohydrate ingestion followed by an exaggerated hyperinsulinemic response. Recent studies have shown that IL-1β contributes to postprandial stimulation of insulin. Furthermore, inhibition of SGLT2 reduces excessive plasma glucose increase. Therefore, we investigated whether inhibition of IL-1β with the IL-1 recep...